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Alemtuzumab is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. In CLL has been used as both a first line and second line treatment. In MS it is generally only recommended if other treatments have not worked. It is given by injection into a vein.. It is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not ...
Alemtuzumab er et humaniseret monoklonalt antistof, der produceres ved rekombinant DNA-teknologi, og som genkender og binder sig til et glykoprotein, CD52, der findes på overfladen af lymfocytter, hvorved disse går til grunde.
Use alemtuzumab (lemtrada) as ordered by your doctor. Read all information given to you. Follow all instructions closely. It is given as an infusion into a vein over a period of time. Other drugs may be given to help with infusion side effects. Make ...
Cases of severe, including fatal, neutropenia have been reported within 2 months of LEMTRADA infusion. Mild to moderate decreases in platelet counts, starting at the time of alemtuzumab infusion have been reported. Consider additional monitoring in patients with medical conditions which predispose them to cardiovascular or pulmonary compromise.
are taking a medicine called Campath ® (alemtuzumab) have received a live vaccine in the past 6 weeks before receiving LEMTRADA or plan to receive any live vaccines. Ask your healthcare provider if you are not sure if your vaccine is a live vaccine; are pregnant or plan to become pregnant. LEMTRADA may harm your unborn baby.
DESCRIPTION. CAMPATH (alemtuzumab) is a recombinant DNA-derived humanized monoclonal antibody (CAMPATH-1H) directed against the 21–28 kD cell surface glycoprotein, CD52.CAMPATH-1H is an IgG1 kappa antibody with human variable framework and constant regions, and complementaritydetermining regions from a murine (rat) monoclonal antibody (CAMPATH-1G).
Alemtuzumab stops these cells from getting into your brain and spinal cord before they can damage the nerves there. Most people only need to take the drug twice, in two courses spaced a year apart from each other. It's given through a drip (known as an infusion) in hospital.
Following a review of alemtuzumab by the European Medicines Agency, a revised indication, additional contraindications (see Contraindications), and strengthened monitoring requirements before, during, and after treatment have been recommended.Healthcare professionals are advised that alemtuzumab should only be used for the treatment of patients with relapsing-remitting multiple sclerosis (RRMS ...
Hos patienter, der behandles med alemtuzumab, skal vitale tegn, inkl. blodtryk, monitoreres før og løbende under infusion med alemtuzumab. Hvis der observeres klinisk signifikante ændringer i de vitale funktioner, bør seponering af infusionen og yderligere monitorering, inkl.