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The antinauseant was removed from market. Registry data found patterns of increase in limb reduction defects, oral clefts and diaphragmatic hernias.
Bendectin How a Commonly Used Drug Caused Birth Defects - Part One by Betty Mekdeci Executive Director Birth Defect Research for Children Nausea and occasional vomiting is often one of the first symptoms heralding pregnancy.
Bendectin was widely prescribed after its introduction in 1956, but costly lawsuits claiming safety issues caused the drug's maker, Merrell Dow, to pull it from the market in 1983. Since then the drug has gone through rigorous testing. For this new approval, the FDA studied Diclegis in 261 women experiencing morning-sickness symptoms related to ...
1. Teratology. 1994 Jul;50(1):27-37. Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. McKeigue PM(1), Lamm SH, Linn S, Kutcher JS.
For many drug companies, birth defect experts, obstetricians and law professors, the Bendectin story is unforgettable. Bendectin is the only drug withdrawn from the market solely because of litigation, said Jeffrey Trewhitt, a spokesman for the Pharmaceutical Research and Manufacturers of America.
According to Merrell Dow, the decision was made not because the drug has been proved hazardous, but because the company's insurance premiums have soared to $10 million a year, only $3 million less than income from the sale of the drug.
Bendectin definition, a brand name for a preparation containing the antihistamine doxylamine succinate and a vitamin supplement, formerly prescribed as an antiemetic and antinauseant in the treatment of morning sickness: suspected of causing birth defects and removed from the market. See more.
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Victims of Bendectin, Debendox, Lenotan & Diclectin. 666 likes · 3 talking about this. For Parents and their Children affected by Bendectin, Debendox,...
Benedictin was prescribed to more than thirty-five million American women from its introduction in 1956 until 1983, when it was withdrawn from the market.