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Mechanism of action. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases (more avidly C-Raf than B-Raf).
Come agisce Nexavar? Il principio attivo di Nexavar, sorafenib, è un inibitore della protein-chinasi. Esso cioè blocca alcuni ...
Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in cell-free assays, respectively.
Anwendungsgebiete und Zulassung. Sorafenib zählt zu den Orphan-Arzneimitteln und ist seit 2006 für einige wenige Indikationen in der EU zugelassen.
Sorafenib (Nexavar) tyrosine kinase inhibitor targeted therapy side effects, how it's given, how it works, precautions and self care tips for treatment of advanced ...
Nexavar is used to treat advanced renal cell carcinoma. Learn about side effects, interactions and indications.
Learn about NEXAVAR (sorafenib), including how it is thought to work, treatment options, and financial support.
Background No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase ...
Easy-to-read patient leaflet for Sorafenib. Includes indications, proper use, special instructions, precautions, and possible side effects.
Use of sorafenib (Nexavar ®) in the treatment of hepatocellular carcinoma: PRODIGE AFEF recommendations